Cell-specific Synergic Effect of Cimicifugoside on Cytotoxicity of Methotrexate

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Cell-specific Synergic Effect of Cimicifugoside on Cytotoxicity of Methotrexate

Cimicifugoside is a triterpenoid originating from the rhizomes of Cimicifuga simplex, and acts to inhibit the subcellular transport of nucleosides. Cimicifugoside, when used in combination with methotrexate, showed a cellspecific synergic effect on the promonocytic leukemia cell line U937, but not on the chronic myelogenetic leukemia cell line K562. Thymidine uptake was more severely inhibited ...

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ژورنال

عنوان ژورنال: Journal of Health Science

سال: 2011

ISSN: 1344-9702,1347-5207

DOI: 10.1248/jhs.57.350